TOPLINE: A urinary DNA methylation test demonstrated high sensitivity and specificity for detecting high-grade or invasive bladder cancer, outperforming both nuclear matrix protein 22 (NMP22) and urine cytology tests in sensitivity. However, the new test’s positive predictive value is suboptimal, indicating limitations in confirming the presence of high-grade or invasive bladder cancer…Read More
After the onset of the COVID-19 pandemic, alcohol use increased sharply in Canada, ultimately leading to a 24% jump in alcohol-related deaths and a 14% rise in alcohol-related hospitalizations during the first 2 years alone, according to new research. The sobering data align with findings in other countries…Read More
An arsenal of highly effective medications now represent pillars in the prevention of chronic kidney disease (CKD) progression, yet with the drugs under-utilized among patients who need them the most, better use of prognostic tools is recommended to help guide treatment, a new review reported. “Leveraging prognostic estimates to guide therapy could help clinicians prescribe […]
TOPLINE: Romosozumab for 12 months followed by alendronate for 24 months leads to greater improvements in lumbar spine bone density and trabecular bone scores than alendronate alone for 36 months in postmenopausal women with type 2 diabetes (T2D) and osteoporosis. METHODOLOGY: Lower trabecular bone scores, which are associated with increased fracture risk…Read More
Use of endovascular thrombectomy offered no benefit in patients with acute ischemic stroke caused by occlusions in distal vessels, findings from three new randomized trials showed. The treatment, which involves mechanically removing the clot, has been established as highly effective in patients with large vessel occlusion stroke…Read More